abstract：BACKGROUND:Gastric Cardiac Cancer (GCC) has high incidence and poor prognosis requiring early screening of high-risk populations. Minichromosome maintenance (MCM) proteins are used as diagnostic-biomarkers in many cancers but not validated for GCC. We evaluate MCM protein 2 (MCM2), comparing it with the validated marke...

journal_title：Histology and histopathology

authors： Liu M,Li JS,Tian DP,Huang B,Rosqvist S,Su M

更新日期：2013-04-01 00:00:00

abstract：INTRODUCTION:Germline mutations in the tumour suppressor gene dyskeratosis congenit 1 (DKC1) cause the cancer prone syndrome called X-linked dyskeratosis congenita. The present study aims to determine whether mutations of the DKC1 gene may also be present in frequent human sporadic cancers (breast, colon and lung cance...

journal_title：Histology and histopathology

authors： Penzo M,Casoli L,Ceccarelli C,Treré D,Ludovini V,Crinò L,Montanaro L

更新日期：2013-03-01 00:00:00

abstract：:Cell shape is mainly determined by biophysical constraints, interacting according to non-linear dynamics upon the basic units provided by the genome. In turn, the specific configuration a cell acquires plays a fundamental, permissive role in modulating gene expression and many other complex biological functions. Cell ...

journal_title：Histology and histopathology

authors： Bizzarri M,Pasqualato A,Cucina A,Pasta V

更新日期：2013-02-01 00:00:00

abstract：:Tumor angiogenesis plays important roles in the pathogenesis and prognosis of lung cancer. Both vascular endothelial growth factor (VEGF) and Dll4/Notch pathways are critical for angiogenesis, whereas their relationship under hypoxia in lung cancer remains unknown. Thus, in the present study, we evaluated the expressi...

journal_title：Histology and histopathology

authors： Yu S,Sun J,Zhang J,Xu X,Li H,Shan B,Tian T,Wang H,Ma D,Ji C

更新日期：2013-02-01 00:00:00

abstract：:Gp96 is the endoplasmic reticulum (ER)-resident molecular chaperone, which is involved in the correction of unfolded proteins, in the activation of proteasome-dependent ER-associated degradation of the misfolded proteins, and in activation of the protein translation that modulates polypeptide traffic into the ER. Furt...

journal_title：Histology and histopathology

authors： Jakovac H,Grebic D,Barac-Latas V,Mrakovcic I,Radosevic-Stasic B

更新日期：2013-01-01 00:00:00

abstract：:Fluoxetine shows controversial lung effects as it prevents pulmonary hypertension in adult rats but exposure during gestation causes pulmonary hypertension in neonatal rats. In the present study, we tested the null hypothesis that the antidepressant drug fluoxetine does not modify the development of bronchopulmonary d...

journal_title：Histology and histopathology

authors： Porzionato A,Zaramella P,Macchi V,Grisafi D,Salmaso R,Baraldi M,Fornaro E,Tassone E,Masola V,Onisto M,Chiandetti L,De Caro R

更新日期：2012-12-01 00:00:00

abstract：:Renal oncocytosis is a recently established disease entity characterized by numerous oncocytic tumors and diffuse involvement of oncocytic changes in renal parenchymal epithelia. In this article, we review this disease with a focus on its clinical and pathobiological aspects. Clinically, renal oncocytosis may occur in...

journal_title：Histology and histopathology

authors： Kuroda N,Tanaka A,Ohe C,Mikami S,Nagashima Y,Sasaki T,Inoue K,Hes O,Michal M,Brunelli M,Martignoni G

更新日期：2012-11-01 00:00:00

abstract：:Representative tumour sections from 468 patients with invasive breast cancer were immunostained for cyclooxygenase-2 (COX-2) and evaluated. The relationships between COX-2 expression, clinical outcome and various clinicopathological variables, including tumour vascularity and disseminated tumour cells (DTC) in the bon...

journal_title：Histology and histopathology

authors： Dhakal HP,Naume B,Synnestvedt M,Borgen E,Kaaresen R,Schlichting E,Wiedswang G,Bassarova A,Holm R,Giercksky KE,Nesland JM

更新日期：2012-10-01 00:00:00

abstract：:Transforming growth factor-β (TGF-β) is a key regulator of extracellular matrix (ECM), and may mediate the development of glomerulosclerosis with accumulation of mesangial matrix. Mesangial cells secrete TGF-β in response to common in vitro fibrogenic stimuli. Yet mesangial immunostaining for active TGF-β1 is frequent...

journal_title：Histology and histopathology

authors： Lee HS

更新日期：2012-09-01 00:00:00

abstract：:The present study describes the use of a microwave processing protocol for the rapid histopathological and immunohistochemical diagnosis of bovine rabies. Immunohistochemistry has been used for rabies diagnosis in formalin-fixed tissue with satisfactory results, although the time to diagnosis is considerably longer th...

journal_title：Histology and histopathology

authors： Abreu CC,Nakayama PA,Nogueira CI,Mesquita LP,Lopes PF,Varaschin MS,Seixas Jdo N,Ferreira E,Bezerra PS Jr

更新日期：2012-09-01 00:00:00

abstract：:Multilocular cystic renal cell carcinoma (MCRCC) accounts for approximately 1 to 2% of all renal tumors. This tumor is currently classified as a subtype of clear cell RCC. Clinically, the majority of these tumors are incidentally found. Macroscopically, the tumor is well demarcated and consists of various-sized cysts....

journal_title：Histology and histopathology

authors： Kuroda N,Ohe C,Mikami S,Inoue K,Nagashima Y,Cohen RJ,Pan CC,Michal M,Hes O

更新日期：2012-08-01 00:00:00

abstract：:Infection with Helicobacter pylori (H. pylori) strains is linked to an increased risk of inflammation and gastric cancer. To investigate the effects of H. pylori on biological characteristics of gastric epithelial cells SGC-7901, derived from human adenocarcinoma, morphological appearances of both the pathogen and the...

journal_title：Histology and histopathology

authors： Wang P,Mei J,Tao J,Zhang N,Tian H,Fu GH

更新日期：2012-08-01 00:00:00

abstract：:The Farnesoid X Receptor (FXR) is a member of the nuclear receptor superfamily of ligand-activated transcription factors, which plays crucial role in bile acid, cholesterol, lipid and glucose metabolism, as well as in the development of atherosclerosis, intestinal bacterial growth and liver regeneration. FXR is also i...

journal_title：Histology and histopathology

authors： Koutsounas I,Giaginis C,Theocharis S

更新日期：2012-07-01 00:00:00

abstract：:Human epithelium contains keratin, which is expressed during differentiation. Depending on the target cell type, different types of keratin are expressed, and their alterations seem to represent changes in cell properties. The basal cells of oral epithelium express keratin 5 (K5), K14, K15 and K19, but their alteratio...

journal_title：Histology and histopathology

authors： Khanom R,Sakamoto K,Pal SK,Shimada Y,Morita K,Omura K,Miki Y,Yamaguchi A

更新日期：2012-07-01 00:00:00

abstract：:Src, a 60 kDa non-receptor tyrosine kinase, is the product of normal c-src of the human genome and member of the Src protein tyrosine kinases family (SFK). As described by Martin and Rous, a genetic recombination between c-src and the RSV oncogene of Rous sarcoma virus results in a modified Src protein, with increased...

journal_title：Histology and histopathology

authors： Chatzizacharias NA,Kouraklis GP,Giaginis CT,Theocharis SE

更新日期：2012-06-01 00:00:00

abstract：:Telocytes (TC) are a class of interstitial cells present in heart. Their characteristic feature is the presence of extremely long and thin prolongations (called telopodes). Therefore, we were interested to see whether or not TCs form networks in normal cardiac tissues, as previously suggested. Autopsy samples of card...

journal_title：Histology and histopathology

authors： Rusu MC,Pop F,Hostiuc S,Curca GC,Jianu AM,Paduraru D

更新日期：2012-06-01 00:00:00

abstract：:Angiogenesis and bone formation are coupled during skeletal development and fracture healing. This relationship, although known for some time, has not been properly explored. Advances in the discovery of how angiogenesis is regulated in physiological processes like embryogenesis, endometrial regeneration and wound hea...

journal_title：Histology and histopathology

authors： Portal-Núñez S,Lozano D,Esbrit P

更新日期：2012-05-01 00:00:00

abstract：:Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used for the purpose of anti-inflammation, antipyretic, and analgesia. For this aim, they are used for the alleviation of pain, fever, and inflammation associated with rheumatoid arthritis, sports injuries, and temporary pain. However, treatment with NSAIDs may ...

journal_title：Histology and histopathology

authors： Aygün D,Kaplan S,Odaci E,Onger ME,Altunkaynak ME

更新日期：2012-04-01 00:00:00

abstract：:Elevated plasma levels of C-reactive protein (CRP) are associated with increased risk of cardiovascular disease. CRP immunoreactive protein is also detected in the lesions of atherosclerosis. However, it is not known whether the CRP contents of atherosclerotic lesions are associated with the initiation and progression...

journal_title：Histology and histopathology

authors： Yu Q,Li Y,Wang Y,Zhao S,Yang P,Chen Y,Fan J,Liu E

更新日期：2012-04-01 00:00:00

abstract：:Discrimination of follicular cell-derived benign and malignant tumors of the thyroid is one of the major problems encountered in surgical pathology. In the present study, we evaluated the immunohistochemical expression of NGAL, an iron-binding protein involved in the infiltrative potential of cancer cells, in a cohort...

journal_title：Histology and histopathology

authors： Barresi V,Leni A,Tuccari G,Barresi G

更新日期：2012-03-01 00:00:00

abstract：:Cancer is the subject of intense research around the world, but many questions about how the disease works remain unanswered. How exactly does cancer start and how do tumours grow? In fact, at present there are ten times more anticancer drugs being tested in clinical trials than there were 15 years ago. However, many ...

journal_title：Histology and histopathology

authors： Romero-Camarero I,Barajas-Diego M,Castellanos-Martín A,García-Martín Á,Varela G,Abad M,Ludeña MD,Pérez-Losada J,Sánchez-García I

更新日期：2012-02-01 00:00:00

abstract：BACKGROUND:Gelatinases include matrix metalloproteinase-2 (MMP-2) and matrix metalloproteinase-9 (MMP-9). The abnormal expressions of gelatinases are implicated in the pathogenesis of extracellular matrix (ECM) accumulation. Apolipo-protein E (apoE) is an important plasma protein in cholesterol homeostasis and plays a ...

journal_title：Histology and histopathology

authors： Zhou TB,Qin YH,Lei FY,Su LN,Zhao YJ,Huang WF

更新日期：2012-02-01 00:00:00

abstract：:In the present work we analyze the cerebellum of chronic parkinsonian monkeys in order to clarify whether chronic mesencephalic depletion is associated with long term activation of the cerebellar neurons in chronic Parkinsonism. In our study, we observed a persistent activation of Purkinje cells in the cerebellum of c...

journal_title：Histology and histopathology

authors： Heman P,Barcia C,Gómez A,Ros CM,Ros-Bernal F,Yuste JE,de Pablos V,Fernandez-Villalba E,Toledo-Cárdenas MR,Herrero MT

更新日期：2012-01-01 00:00:00

abstract：:The present study investigated the chemical coding of mammary gland-projecting dorsal root ganglia (DRG) neurons using double-labelling immunohistochemistry. Earlier investigations revealed the presence of Fast blue - positive (FB+) neurons in Th9-Th12 DRG after injection of the tracer into the second, right thoracic ...

journal_title：Histology and histopathology

authors： Franke-Radowiecka A

更新日期：2011-12-01 00:00:00

abstract：:TIMPs in the prostates of male and female gerbils and evaluated the effects of testosterone on the expression of these enzymes. Ventral prostates from male gerbils that were either intact or had been castrated for 7 or 21 days, along with prostates from female gerbils that were either intact or had been treated with t...

journal_title：Histology and histopathology

authors： Rochel-Maia SS,Santos FC,Vilamaior PS,Justulin LA Jr,Felisbino SL,Góes RM,Taboga SR

更新日期：2011-11-01 00:00:00

abstract：:Osteoarthritis (OA) is characterized by cartilage attrition, subchondral bone remodeling, osteophyte formation and synovial inflammation. Perturbed homeostasis caused by inflammation, oxidative stress, mitochondrial dysfunction and proapoptotic/antiapoptotic dysregulation is known to impair chondrocyte survival in joi...

journal_title：Histology and histopathology

authors： Musumeci G,Loreto C,Carnazza ML,Strehin I,Elisseeff J

更新日期：2011-10-01 00:00:00

abstract：:A current concern about the biological effects of electromagnetic fields (EMF) is increasing with the wide spread use of X-band microwaves (MW, 8-10 GHz range). Gigahertz transverse electromagnetic (GTEM) field flat transmission lines are currently being used for experimental exposure of biological samples to high fre...

journal_title：Histology and histopathology

authors： Pérez-Bruzón RN,Del Moral A,Pérez-Castejón C,Llorente M,Vera A,Azanza MJ

更新日期：2011-09-01 00:00:00

abstract：BACKGROUND AND RESULTS:Embryos from diabetic mice exhibit several forms of neural tube defects, including non-closure of the neural tube. In the present study, embryos collected at embryonic day 11.5 from diabetic pregnancies displayed open neural tube with architectural disruption of the surrounding tissues. The perce...

journal_title：Histology and histopathology

authors： Loh WT,Dheen ST,Jiang B,Kumar SD,Tay SS

更新日期：2011-08-01 00:00:00

abstract：:Endometriosis is a chronic pelvic inflammatory process. Local inflammation is known to play a role in pain and infertility associated with the disease, and may be extensively involved in molecular and cellular processes leading to endometriosis development. In this review, we focus on two inflammatory mediators clearl...

journal_title：Histology and histopathology

authors： Defrère S,González-Ramos R,Lousse JC,Colette S,Donnez O,Donnez J,Van Langendonckt A

更新日期：2011-08-01 00:00:00

abstract：:β-lapachone is a quinone of lapachol extracted from the bark of lapacho tree. Recent findings demonstrated that punched skin wounds of mice healed faster with β-lapachone treatment. The present study investigates the effects of β-lapachone on burn-wound skin of C57BL/6 mice injured by a 100 °C iron stick. Our results ...

journal_title：Histology and histopathology

authors： Fu SC,Chau YP,Lu KS,Kung HN

更新日期：2011-07-01 00:00:00

abstract：:Cyclin A, cyclin E, BUBR1, MAD2 and Aurora A are all cell-cycle regulatory proteins and have been proven to play crucial roles in carcinogenesis. However, their expression patterns in invasive ductal breast carcinoma (IDBC) are controversial and unclear. In this study, we examined the expression status of these candid...

journal_title：Histology and histopathology

authors： Du J,Du Q,Zhang Y,Sajdik C,Ruan Y,Tian XX,Fang WG

更新日期：2011-06-01 00:00:00

abstract：:Anthracyclines are one of the most effective anticancer drugs ever developed, but their clinical use has been hampered by the risk of severe cardiotoxicity. In this study, we investigated whether rabbits exposed to a different cumulative dose of anthracycline suffer from immunohistochemically detectable vascular toxic...

journal_title：Histology and histopathology

authors： Nachtigal P,Sterba M,Popelová O,Večeřová L,Kudláčková Z,Jirkovský E,Geršl V

更新日期：2011-05-01 00:00:00

abstract：:Primordial germ cells (PGCs) are the founder cells of all gametes. PGCs differentiate from pluripotent epiblasts cells by mesodermal induction signals during gastrulation. Although PGCs are unipotent cells that eventually differentiate into only sperm or oocytes, they dedifferentitate to pluripotent stem cells known a...

journal_title：Histology and histopathology

authors： Kimura T,Nakano T

更新日期：2011-05-01 00:00:00

abstract：:The integrity of the thymus during early life is necessary for a proper maturation of the neuroendocrine system, including the adrenal axis. The thymic metallopeptide thymulin seems to be a central physiologic mediator of thymus-pituitary communication. Furthermore, neonatal thymulin gene therapy has been shown to pre...

journal_title：Histology and histopathology

authors： Martines E,Reggiani PC,Schwerdt JI,Goya RG,Cónsole G

更新日期：2011-04-01 00:00:00

abstract：:We examined morphological characteristics of the carotid body of spontaneously hypertensive rats (SHR), those of age-matched normotensive Wistar rats (NWR), and age-matched genetically comparable Wistar Kyoto rats (WKY). We examined the distribution and abundance of four different regulatory neuropeptides: substance P...

journal_title：Histology and histopathology

authors： Takahashi M,Matsuda H,Hayashida Y,Yamamoto Y,Tsukuda M,Kusakabe T

更新日期：2011-03-01 00:00:00

abstract：:We compared characteristic lesions occurring in chickens and domestic ducks naturally infected with H5N1 HPAI virus in April and May 2008. Infected chickens generally exhibited pale-green, watery diarrhoea, depression, neurological signs and cyanosis of wattles and combs, and infected ducks generally exhibited neurolo...

journal_title：Histology and histopathology

authors： Woo GH,Kim HY,Bae YC,Jean YH,Bak EJ,Kim MJ,Hwang EK,Joo YS

更新日期：2011-02-01 00:00:00

abstract：:The view of how astrocytes, a type of glial cells, contribute to the functioning of the central nervous system (CNS) has changed greatly in the last decade. Although glial cells outnumber neurons in the mammalian brain, it was considered for over a century that they played a subservient role to neurons. This view chan...

journal_title：Histology and histopathology

authors： Potokar M,Stenovec M,Kreft M,Gabrijel M,Zorec R

更新日期：2011-02-01 00:00:00

abstract：:We designed to investigate the effects of down-regulating the tumor susceptibility gene 101 (TSG101) on the proliferation and apoptosis of the human breast cancer MCF-7 cell line, and the role of the MAPK/ERK signal pathway in this process. The siRNA against TSG101 was transfected into the breast cancer MCF-7 cell lin...

journal_title：Histology and histopathology

authors： Zhang Y,Song M,Cui ZS,Li CY,Xue XX,Yu M,Lu Y,Zhang SY,Wang EH,Wen YY

更新日期：2011-01-01 00:00:00

abstract：:Spectrins are members of the superfamily of F-actin cross linking proteins that are important as scaffolding proteins for protein sorting, cell adhesion, and migration. In addition, spectrins have been implicated in TGF-beta signaling. The aim of the present study was to analyze the expression and localization of beta...

journal_title：Histology and histopathology

authors： Jiang X,Gillen S,Esposito I,Giese NA,Michalski CW,Friess H,Kleeff J

更新日期：2010-12-01 00:00:00

abstract：:The vacuolar-type H(+)-ATPases (V-ATPases) are a family of multi-subunit ATP-dependent proton pumps involved in diverse cellular processes, including acid/base homeostasis, receptor-mediated endocytosis, processing of proteins and signaling molecules, targeting of lysosomal enzymes, and activation of various degradati...

journal_title：Histology and histopathology

authors： Sun-Wada GH,Wada Y

更新日期：2010-12-01 00:00:00